CALUX assays (ER, AR, GR) Back to list of tests

CALUX assays (ER, AR, GR)

Description:

Assessment of chemical (or sample) potencies to activate receptor-dependent luciferase reporter gene in mammalian cell line (mechanism of endocrine disruption via estrogen ER, androgen AR, glukocorticoid GR receptors)

Reference:
Legler J. et al. (1999) Toxicol Sci.48(1):55-66.

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative: