Receptor binding assays (ER, AR, TR) Back to list of tests

Receptor binding assays (ER, AR, TR)


Assessment of chemical (or sample) potencies to bind to isolated receptors such as estrogen (ER), androgen (AR) or thyroid - indication of endocrine disruption.

Loomis, A.K., Thomas, P. (1999) Biol. Reprod. 61, 51-60; Rider, C.V. et al. (2009) Environ Toxicol Chem 28, 2175-2181; Tollefsen, K., (2002) General and Comparative Endocrinology 126, 14-22.

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:


Other references: 

Androgen receptor -  Sperry, T.S. (2000) Journal of Steroid Biochemistry and Molecular Biology 73, 93-103.

Thyroid receptor - Morgado, I. (2007) Chemosphere 69, 155-163.