Receptor binding assays (ER, AR, TR) Back to list of tests

Receptor binding assays (ER, AR, TR)

Description:

Assessment of chemical (or sample) potencies to bind to isolated receptors such as estrogen (ER), androgen (AR) or thyroid - indication of endocrine disruption.

Reference:
Loomis, A.K., Thomas, P. (1999) Biol. Reprod. 61, 51-60; Rider, C.V. et al. (2009) Environ Toxicol Chem 28, 2175-2181; Tollefsen, K., (2002) General and Comparative Endocrinology 126, 14-22.

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:

Details:

Other references: 

Androgen receptor -  Sperry, T.S. (2000) Journal of Steroid Biochemistry and Molecular Biology 73, 93-103.

Thyroid receptor - Morgado, I. (2007) Chemosphere 69, 155-163.