Stepdown approach Back to list of tests

Stepdown approach


Test results (EC50) of lower organisms (algae, and daphnids) are evaluated, in the absence of fish LC50 data to derive PNECwater values.

Hutchinson T., H. et al. (2003) Environ.Toxicol. Chem. 22(12), 3031-3036

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:


Another reference: OECD (2010b) . Number 126. Short Guidance on the Threshold approach for Acute Fish Toxicity. ENV/JM/TG(2010)/7