Experimental design - fish endocrine disruption Back to list of tests

Experimental design - fish endocrine disruption


Improvement of the reproduction test experimental design - reduction in number of animals & number of concentrations used. Statistical power remains at similar level as in the standard assay.

Bosker T. et al. (2009) Environ Toxicol Chem. 28 (11), 2386-2396..

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Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:


Additional ref: Bosker T, Hewitt LM, Munkittrick KR, MacLatchy DL. (2010). Validation of a refined short-term adult fish reproductive test with improved power for mummichog (Fundulus heteroclitus) to test complex effluents. Ecotoxicol Environ Saf. 73(7), 1596-1601.