Experimental design - fish acute toxicity Back to list of tests

Experimental design - fish acute toxicity

Description:

Improvement of the acute toxicity test experimental design - reduction in number of animals & number of concentrations used. Statistical power remains at similar level as in the standard assay.

Reference:
OECD (2011). Draft Guidance and Review Documents/Monographs. Draft Fish Testing Framework document. Chapters 1-8 / Rufli H., Springer T.A. (2011). Environ. Toxicol. Chem. 30, 1006-1011.

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:

Details:

OECD (2011). Draft Guidance and Review Documents/Monographs. Draft Fish Testing Framework document. Chapters 1-8. Available: http://www.oecd.org/document/12/0,3746,en_2649_34377_1898188_1_1_1_1,00.html