Sawle et al. Toxicol Sci. 2010 Nov;118(1):128-39. Epub 2010 Aug 11
Categorization of the assay/approach:
Status of the assay:
Categorization according to "exposure duration/effect":
Categorization according to combination of type of effect, endpoint measured and/or method used:
Categorization according to what "R" from the "3R" concept is this assay an alternative:
Large-scale toxicogenomic screening used to unravel toxicological effects and modes of action of chemicals and ecotoxicants. They have trialled a more intensive approach to the design and interpretation of array experiments incorporating a balanced interwoven ANOVA design with higher levels of biological replication, a more thorough analysis of errors and false discovery rates, and an analysis of response patterns using gene network models.