Scholz et al. Environ Sci Pollut Res Int. 2008 Jul;15(5):394-404. Epub 2008 Jun 25. Review.
Categorization of the assay/approach:
Status of the assay:
Categorization according to "exposure duration/effect":
Categorization according to combination of type of effect, endpoint measured and/or method used:
Categorization according to what "R" from the "3R" concept is this assay an alternative:
Reviewed the scientific literature in order to indicate alternative applications of the fish embryo model with focus on embryos of the zebrafish beyond the application for determining the acute toxicity, especialy studies aimed at the understanding of toxic mechanisms and the indication of possible adverse and long-term effects.