Mekenyan et al; Curr Pharm Des. 2004;10(11):1273-93.
Categorization of the assay/approach:
Status of the assay:
Categorization according to "exposure duration/effect":
Categorization according to combination of type of effect, endpoint measured and/or method used:
Categorization according to what "R" from the "3R" concept is this assay an alternative:
Tissue metabolism simulator (TIMES), which uses a heuristic algorithm to generate plausible metabolic maps from a comprehensive library of biotransformations and abiotic reactions and estimates for system-specific transformation probabilities.