Amphibian Luc assay Back to list of tests

Amphibian Luc assay

Description:

Assay for detecting of the thyroid disrupting activity of tested substance

Reference:
Murata and Yamauchi, Toxicol Appl Pharmacol. 2008 Feb 1;226(3):309-17

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:

Details:

interference with the cellular T(3)-signaling pathway through TR-mediated luciferase gene activation (the luc assay) of tested substance