ZFET bevioural response Back to list of tests

ZFET bevioural response

Description:

Various behavioural assays (photomotor response, locomotion, optokinetic response, touch-evoked response) are used to detect neurotoxic/neuroactive effects or effects on the visual system.

Reference:
Richards FM, J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):50-8. Epub 2008 May 2.

Categorization of the assay/approach:

Status of the assay:

Application domain:

Categorization according to "exposure duration/effect":

Categorization according to combination of type of effect, endpoint measured and/or method used:

Categorization according to what "R" from the "3R" concept is this assay an alternative:

Details:

Richards FM, J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):50-8. Epub 2008 May 2. - The optomotor response (OMR) assay. Selected compounds were also tested in the optokinetic response (OKR) and locomotor assays. OMR assay in zebrafish could be useful in predicting the adverse effects of drugs on visual function in man and would support its potential as a screen for 'frontloading' safety pharmacology assessment of this endpoint in vivo.
 

Other references: 

Rihel Jason; Prober David A.; Arvanites Anthony; et al. (2010) Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation. SCIENCE 327 (5963) 348-351 DOI: 10.1126/science.1183090 Published: JAN 15 2010